Connect with us

Hi, what are you looking for?

Health

Seizure Drug May Help Ease Symptoms of Major Form of Dementia

WEDNESDAY, Jan. 24, 2018 (HealthDay News) — A drug normally used to treat seizures may help ease som..

WEDNESDAY, Jan. 24, 2018 (HealthDay News) — A drug normally used to treat seizures may help ease some symptoms that occur with a type of dementia known as Lewy body dementia, researchers are reporting.

The drug is called zonisamide (Zonegran). When added to treatment with the drug levodopa, zonisamide helped to control Parkinson's disease-like movement symptoms that are associated with Lewy body dementia. These symptoms may include tremors, stiffness, slowness and trouble walking.

This finding could be significant, dementia researchers said.

While higher doses of levodopa can also help control movement symptoms, they can cause serious psychiatric side effects, including hallucinations, in people with Lewy body dementia. Zonisamide didn't appear to increase psychiatric problems or worsen memory troubles in this 12-week study from Japan.

"Movement symptoms in Lewy body dementia are problematic to treat with standard Parkinson's disease medications, because they can provoke hallucinations," said Dr. Daniel Kaufer, director of the University of North Carolina Chapel Hill Memory Disorders Program. Kaufer wasn't involved in the new research.

"Zonisamide improved motor function in a dose-dependent manner, without inducing serious side effects," Kaufer said.

However, the drug would not have any effect on the memory problems associated with this type of dementia, he said.

Lewy body dementia affects about 1.4 million people in the United States, and is the second most common type of dementia after Alzheimer's disease, according to the Lewy Body Dementia Association.

Symptoms vary, but may include memory and thinking problems, difficulty understanding visual information, trouble with attention, Parkinson's-like movement symptoms, hallucinations and changes in sleep or behavior.

Kaufer said treatment options for this and other neurodegenerative diseases are limited, so any advance is welcome. Zonisamide is already approved by the U.S. Food and Drug Administration for treatment of seizures.

The study was led by Dr. Miho Murata from the National Center of Neurology and Psychiatry in Tokyo and sponsored by zonisamide's Asian manufacturer, Sumitomo Dainippon Pharma, in Japan.

It included 158 people diagnosed with probable Lewy body dementia. (As with other forms of dementia, the only way to definitively diagnose Lewy body dementia is after death with an autopsy.)

The study volunteers were already receiving treatment with the Parkinson's drug levodopa.

They were given a placebo for four weeks at the start of the study. Then they were randomly placed into one of three groups that received a placebo, 25 milligrams or 50 milligrams of zonisamide once daily.

The participants who received the highest dose of zonisamide had the most improvement in their movement symptoms compared to a placebo. Those who received the smaller dose had slight improvements over a placebo, according to the study.

Kaufer said the drug showed a clear-cut dose response, which indicates the medication is working.

"This study identifies another potential therapeutic option for a circumstance that is not uncommon. The results weren't earth-shattering, but zonisamide could be a viable treatment option to improve quality of life," he said.

Dr. Sami Saba, a neurologist at Lenox Hill Hospital in New York City, agreed that zonisamide could be beneficial.

"Zonisamide looks pretty effective at improving movement symptoms and not causing psychiatric symptoms," said Saba, who wasn't involved in the research.

"This is known to be a difficult disease to treat, and this adds to the cadre of things we can use that may help this subset of patients," he added.

The study authors noted that the current study size was small, and said a larger study is needed.

The findings were published online Jan. 24 in the journal Neurology.

More information

Learn more about Lewy body dementia from the Lewy Body Dementia Association.

Original Article

[contf]
[contfnew]

Health

[contfnewc]
[contfnewc]

53 Comments

53 Comments

  1. hydroxcloroquine

    July 28, 2021 at 3:09 pm

    hydroxychloroquine for malaria https://plaquenilx.com/# hydroxychloroquine sulfate tabs 200mg

  2. hydroxychloroquine classification

    August 1, 2021 at 1:14 am

    how safe is hydroxychloroquine https://plaquenilx.com/# what is hydroxychloroquine sulfate

  3. PatrickSep

    August 27, 2021 at 12:45 pm

    cialis coupon cialis 20 mg

  4. hydroxychloroquineEi

    August 31, 2021 at 4:22 am

    antimalarial drugs hydroxychloroquine what is hydroxychloroquine sulfate hydroxy chloroquine

  5. cialis coupon

    September 2, 2021 at 9:19 am

  6. zithromaxeser

    September 14, 2021 at 3:20 pm

    z pak strength what is zithromax 250 mg used for zithromax tablets

  7. hydroxychloroquineEi

    September 18, 2021 at 6:41 am

    chloroquine phosphate online is hydroxychloroquine an immunosuppressant hydroxychloroquine drugs

  8. accutane medication

    September 25, 2021 at 1:46 am

    https://accutaneisotretinoine.com/ isotretinoin side effects

  9. modalert200

    September 25, 2021 at 1:46 am

    armodafinil vs modafinil modafinil prescription online

  10. prednisonedosepack

    September 25, 2021 at 2:19 am

    prednisone without prescription prednisone drops after cataract surgery

  11. bactrim antibiotic

    September 25, 2021 at 2:19 am

    What dose of co- trimoxazole is used in a patient with a UTI? sulfamethoxazole 800 mg trimethoprim

  12. modafinilhalflife

    September 25, 2021 at 2:19 am

    provigil prescription provigil vs modafinil

  13. plaquenil eye exam

    September 26, 2021 at 8:27 am

  14. hydroxychloroquine drugs

    September 29, 2021 at 12:20 am

    hydroxychloroquine https://plaquenilx.com/# hcqs tablet

  15. pharmaceptica

    September 29, 2021 at 3:43 pm

    sildenafil 40 mg over the counter https://pharmaceptica.com/

  16. prednisonemedicine

    October 2, 2021 at 4:38 am

    buy prednisolone online uk is prednisone a steroid

  17. provigilandalcohol

    October 2, 2021 at 8:38 am

    modafinil dosage provigil dosage

  18. buy isotretinoine

    October 2, 2021 at 8:38 am

    buy accutane accutane medication

  19. modalert

    October 2, 2021 at 11:20 am

    modafinil online modafinil

  20. bactrim ds

    October 2, 2021 at 12:11 pm

    Sulfamethoxazole and alcohol sulfamethoxazole generic name

  21. isotretinoina

    October 9, 2021 at 1:32 am

    isotretinoine buy isotretinoin

  22. modafinildosage

    October 9, 2021 at 1:32 am

    modafinil smart drug https://provigilandmodafinil.com/

  23. ordermodafinil

    October 9, 2021 at 1:36 pm

    provigil vs modafinil modafinil reviews

  24. bactrim antibiotic

    October 9, 2021 at 1:36 pm

    https://bactrimsulfamethoxazole.com/ Sulfamethoxazole trimethoprim

  25. prednisonetaper

    October 15, 2021 at 6:50 pm

  26. isotretinoine

    October 15, 2021 at 6:50 pm

  27. modafinilmoa

    October 16, 2021 at 3:24 am

    provigil vs modafinil modalert 200

  28. bactrim ds 800 160

    October 16, 2021 at 3:24 am

  29. Fawadvatygev

    October 22, 2021 at 1:19 am

    hydroxychloroquine update today chloroquine structure

  30. evilawfry

    October 22, 2021 at 1:19 am

    aralen medication plaquenil oct

  31. Fawadvatckuh

    October 22, 2021 at 9:00 am

  32. Fawadvattijl

    October 22, 2021 at 9:00 am

  33. Fawadvatvvkp

    October 22, 2021 at 5:08 pm

  34. Fawadvatbbth

    October 28, 2021 at 3:05 am

  35. evilarzly

    October 28, 2021 at 3:21 am

    hydroxychloroquine 200 mg tablet https://chloroquineclinique.com/

  36. Fawadvatgulq

    October 28, 2021 at 9:37 am

  37. Fawadvatomft

    October 28, 2021 at 10:40 am

    plaquenil immunosuppressive doctors for hydroxychloroquine

  38. Fawadvatvxfm

    October 28, 2021 at 10:13 pm

    where to buy chloroquine hydroxychloroquine plaquenil

  39. Fawadvatxfcp

    November 3, 2021 at 11:34 am

    plaquenil online plaquenil buy online

  40. evilaajuf

    November 3, 2021 at 11:34 am

    side effects of plaquenil hydroxychloride medicine

  41. Fawadvatytlz

    November 3, 2021 at 11:26 pm

  42. Fawadvategmh

    November 4, 2021 at 12:59 am

    hydroxychloroquine malaria hydroxychloroquine side effects

  43. Fawadvatljjc

    November 4, 2021 at 5:22 pm

    https://hydroxychloroquin1mg.com/ chloroquine malaria

  44. Fawadvatpmfs

    November 9, 2021 at 7:54 pm

    plaquenil pregnancy aralen medication

  45. Fawadvatafim

    November 10, 2021 at 3:38 pm

    can i buy chloroquine over the counter plaquenil buy online

  46. Fawadvateaoa

    November 11, 2021 at 12:49 am

  47. Fawadvatpxol

    November 11, 2021 at 6:29 am

    side effects of plaquenil is plaquenil an immunosuppressant

  48. Fawadvatqeyu

    November 18, 2021 at 7:20 am

    what are the side effects of hydroxychloroquine chloroquine cvs

  49. evilaevov

    November 18, 2021 at 7:20 am

    hydroxychloroquine pills hydroxychloroquine dose

  50. Fawadvathpqa

    November 20, 2021 at 5:42 am

    hydroxychloroquine and zinc what is chloroquine

  51. Fawadvatjwbw

    November 20, 2021 at 7:56 pm

  52. Fawadvatxwvc

    November 21, 2021 at 2:07 am

    chloroquine primaquine chloroquine for sale

Leave a Reply

Your email address will not be published.