BRITISH scientists thought to be leading the global race to develop a COVID-19 vaccine are close to a major breakthrough according to reports.
The life-saving antibody treatment developed by Oxford University has been hailed as potentially vital for the elderly and vulnerable, whose bodies may not respond well to a vaccine. Millions of doses of the treatment is already being manufactured by pharmaceutical giant AstraZeneca in the expectation that it will work.
The vaccine, named ChAdOx1 nCoV-19, is made from a weakened version of the common cold virus, which causes infections in chimpanzees.
The virus has been manipulated to not cause harm to humans, but contains part of COVID-19 so to trigger the body’s immune response to the virus’s spike proteins, which it uses to enter human cells and multiply.
A separate project to create an antibody treatment for those especially vulnerable to COVID-19 is also being developed, with the team confident it will prove successful.
Testing for the treatment is now said to be moving at “full speed”.
Pascal Soriot, chief executive of AstraZeneca, has described the treatment as a “combination of two antibodies” in an injected dose.
This kind of treatment should reduce the chance that someone would develop resistance to one of them.
He told The Sunday Telegraph that the treatment could be vital for the elderly and vulnerable, “who may not be able to develop a good response to the vaccine”.
However, healthy people can develop antibodies to a disease to fight off the infection and protect them from it in future, meaning coronavirus antibody testing has become a key priority for governments around the world.
Thousands of frontline NHS staff have started being given antibody tests for COVID-19 to find out if they have had it.
However, scientists are still uncertain as to whether antibodies provide guaranteed immunity to the virus.
While an effective antibody treatment could be vital for some, Mr Soriot told The Sunday Telegraph the vaccine remains the priority.
He explained that production for antibody therapies is far more expensive than it is for vaccines.
Mr Soriot has previously suggested that scientists will know by July if the Oxford vaccine will work.
AstraZeneca has signed deals ensuring millions of doses of the Oxford vaccine can be manufactured if it works.
One is with Microsoft founder Bill Gates, to supply doses to low and middle-income countries; the other is with the Coalition for Epidemic Preparedness Innovations.
Around 30 million could be made available in the UK as early as September, Downing Street has said.
However, some scientists have expressed caution over how soon any vaccine could be made available.
Trials are ongoing in the UK and have also got started in Brazil, after concerns that the UK’s falling transmission rate could stifle the work being done.
Under the leadership of President Jair Bolsonaro, Brazil has become one of the epicentres of the disease.
The president has been accused of repeatedly downplaying the threat of COVID-19 as cases rise across South America.
Brazil is second to the US in the number of cases globally, with more than 670,000, and has reported 35,930 deaths.
According to Johns Hopkins University figures, worldwide coronavirus deaths currently stand at 401,564.
Cases are now approaching 7 million, with 6,973,195 currently confirmed.
The US, has the highest deaths and infections globally, has 1,931,850 confirmed cases and 110,141 deaths.