{"id":98125,"date":"2018-11-05T21:00:17","date_gmt":"2018-11-05T21:00:17","guid":{"rendered":"https:\/\/www.bnreport.com\/a-mashup-of-yeast-and-e-coli-shows-how-mitochondria-might-have-evolved\/"},"modified":"2018-11-05T21:00:17","modified_gmt":"2018-11-05T21:00:17","slug":"a-mashup-of-yeast-and-e-coli-shows-how-mitochondria-might-have-evolved","status":"publish","type":"post","link":"https:\/\/www.bnreport.com\/en\/a-mashup-of-yeast-and-e-coli-shows-how-mitochondria-might-have-evolved\/","title":{"rendered":"A mashup of yeast and E. coli shows how mitochondria might have evolved"},"content":{"rendered":"

Yeast intentionally stuffed with bacteria may teach scientists something about the origins of cells powerhouses.<\/p>\n

Cellular power-generating organelles, called mitochondria, are thought to have once been bacteria captured by archaea, single-celled microbes that are one of the earliest forms of life. Now, almost all eukaryotic cells (cells with a nucleus) contain mitochondria. At first, the bacteria may have lived inside archaea as endosymbionts, independent organisms that cooperate with their hosts. Over time, mitochondria lost many of their genes and eventually became an integral part of the cell.<\/p>\n

This scenario has support from genetics. But \u201cif you really want to prove somethings true,\u201d says chemical biologist Peter Schultz, researchers should be able to make something similar in the lab. So Schultz, of the Scripps Research Institute in La Jolla, Calif., and his colleagues created a hybrid cell<\/a> by fusing two popular lab organisms \u2014 the bakers yeast Saccharomyces cerevisiae<\/em> and a common gut bacteria called E. coli<\/em>.<\/p>\n

\u201cIts a pioneering approach,\u201d says evolutionary biologist Antonio Lazcano of the National Autonomous University of Mexico in Mexico City, who was not involved in the experiments. No one has made such a hybrid organism before. But the work, described October 29 in the Proceedings of the National Academy of Sciences,<\/em> suggests it may not be so hard to make a free-living organism into an endosymbiont, he says.<\/p>\n

Not that it was easy to get bacteria adapted to living on their own to grow inside another species cells. First, the researchers had to give the yeast and bacteria a reason to team up.<\/p>\n

Schultzs team disabled a gene in yeasts mitochondria so that the organelles couldnt produce chemical energy in the form of adenosine triphosphate, or ATP, under some circumstances. E. coli<\/em> were engineered to lack a gene needed to make the B vitamin thiamine, which the bacteria need to live. The team also outfitted the bacteria with a transporter protein that can move ATP and its precursor adenosine diphosphate, or ADP, in or out of the cell. When the bacteria was put inside the yeast cells, the bacteria supplied the ATP the yeast needed to live, and the yeast made thiamine for the bacteria.<\/p>\n

It wasnt a perfect arrangement, though. The yeast kept digesting the bacteria. So Schultzs team equipped the E. coli<\/em> with SNARE proteins from Chlamydia trachomatis<\/em> bacteria, which can live inside human cells and cause the sexually transmitted disease chlamydia. SNARE proteins can prevent a host cells digestive compartments, called lysosomes, from coming together to dismantle invading microbes. SNARE-outfitted E. coli<\/em> eventually were able to grow inside the yeast cell, the researchers found. The hybrid yeast-bacteria cells grew for more than 40 generations, the researchers report.<\/p>\n

Theres no way to know the exact environmental and physiological conditions microbes faced that led to formation of eukaryotic cells 1.5 billion years ago, says evolutionary biologist Ryan Gawryluk of the University of Victoria in Canada who was not involved in the work. Exchanging energy for nutrients may have been one impetus for bacteria and archaea to join forces, but some scientists dont think it was the evolutionary force that shaped the partnership, he says. After all, \u201cbacteria have no interest in sending ATP outside of their cells.\u201d Mitochondria-precursor bacteria may have been parasites or endosymbionts that gradually lost the ability to live outside the host for other reasons.<\/p>\n

Still, Gawryluk says, the new study offers \u201can exciting result \u2026 showing how this potentially could have happened.\u201d<\/p>\n

<\/a><\/strong> <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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