{"id":64042,"date":"2018-02-16T14:05:25","date_gmt":"2018-02-16T14:05:25","guid":{"rendered":"http:\/\/www.bnreport.com\/probe-provides-rapid-lung-investigation-2\/"},"modified":"2018-02-16T14:05:25","modified_gmt":"2018-02-16T14:05:25","slug":"probe-provides-rapid-lung-investigation-2","status":"publish","type":"post","link":"https:\/\/www.bnreport.com\/en\/probe-provides-rapid-lung-investigation-2\/","title":{"rendered":"Probe provides rapid lung investigation"},"content":{"rendered":"<figure>\n<p>Media playback is unsupported on your device<\/p>\n<\/figure>\n<p>Scientists have developed a probe that for the first time goes inside the lung to find bacterial infections. <\/p>\n<p>Currently, this is done by sending samples to a laboratory and waiting several days for the results. <\/p>\n<p>The new approach was inspired by the 1960s film Fantastic Voyage, in which a submarine shrinks to microscopic size to enter a human body. It is even <a href=\"https:\/\/proteus.ac.uk\/\" rel=\"noreferrer\" target=\"_blank\">called Proteus<\/a> after that sci-fi sub. <\/p>\n<p>The project has been unveiled at a US science meeting in Texas.<\/p>\n<p>In the film, the team enters the body of an important scientist to save him from a blood clot in his brain.<\/p>\n<p>Drawing on this theme, a group of doctors and scientists from Edinburgh, Bath and Heriot-Watt Universities in the UK developed a system for sending a probe inside a patient&#039;s lung.<\/p>\n<p>I watched the procedure. I could see the probe journeying through the tiny airways from its on board camera until it came across bacteria.<\/p>\n<p>The inside of the patient&#039;s lung had been sprayed earlier with a chemical that makes the bacteria visible when light from the probe is shone on them.<\/p>\n<p>The Proteus probe enables doctors to see infection inside the human body for the very first time, according to Prof Kevin Dhaliwal of Edinburgh University, who leads the project.<!--more--><\/p>\n<p>&quot;The real advantage is that we are actually imaging and detecting where the disease is in the patient&#039;s lungs and we are giving a diagnosis and a decision-making power within minutes or seconds. That&#039;s a big difference.&quot;<\/p>\n<p>Currently, samples need to be taken from patients and analysed in labs. The process can take days and can often give unreliable results. <\/p>\n<p>The team is using its technology to test if critically ill people are developing pneumonia. <\/p>\n<p>Patients in intensive care are given broad-spectrum antibiotics just in case they have the infection. But there is a huge downside. Complications can develop as the antibiotics interact with the patient&#039;s other medication and clinical studies indicate that as a result tens of thousands of people worldwide die.<\/p>\n<p>The use of antibiotics in this way also increases the risk of antibiotic-resistant strains emerging. The Proteus system can identify the precise strain of the bacteria and therefore enable doctors to prescribe the appropriate antibiotic, according to Dr Anya Bruce, who is a project manager for the Proteus initiative.<\/p>\n<p>&quot;There is a huge over-use of antibiotics,&quot; she told BBC News. &quot;Clinicians do not have the answers at their fingertips when administering broad-spectrum antibiotics but this technology could give them the information about what they are trying to treat.&quot;<\/p>\n<p>In principle, the technique could be used to detect many other conditions inside the body, such as fungi and cancer, according to Prof Dhaliwal.<\/p>\n<p>&quot;Our team is making rapid progress in bringing together many technologies to help us develop entirely new approaches to diagnose and treat disease at the bedside.&quot; <\/p>\n<p>Prof Dhaliwal is collaborating with Prof Gerard Cote at Texas A&amp;M University in College Station to use the same technique to develop cheap, portable tests for a range of diseases, including diabetes and coronary heart disease. <\/p>\n<p>Prof Cote has also developed a system to detect malaria by shining light on a blood sample. Aid workers in the field can see straight away if a patient is infected and provide appropriate medication.<\/p>\n<p>Currently, this can only be done by sending blood samples to a large hospital where each one has to be checked by eye under a microscope. Each sample can take several hours to analyse. <\/p>\n<p>Prof Cote aims to have his system incorporated into a tablet device or smartphone so that immediate diagnoses can be made in poor and remote areas.<\/p>\n<p>&quot;The main global need is to diagnose malaria in the field. And it will have a huge impact, particularly for infants and the elderly who are dying at a tremendous rate in these underserved areas of the world,&quot; Prof Cote said.<\/p>\n<p>Details of the new system were given at the <a href=\"http:\/\/meetings.aaas.org\/\" rel=\"noreferrer\" target=\"_blank\">annual meeting of the American Association for the Advancement of Science<\/a> in Austin, Texas.<\/p>\n<p>Prof Philip Nelson, chief executive of the UK Engineering and Physical Sciences Research Council (EPSRC), which funded the research, commented: &quot;This new technology developed by the Proteus team is a clear example of how scientists, engineers and medics can collaborate internationally to produce life-saving techniques for diagnosis and treatment.&quot;<\/p>\n<p>Proteus has also received funding from the Medical Research Council, the Wellcome Trust, and CARB-X, the world&#039;s largest public-private partnership devoted to antibacterial early development research.<\/p>\n<p><a href=\"https:\/\/twitter.com\/bbcpallab\" rel=\"noreferrer\" target=\"_blank\">Follow Pallab on Twitter<\/a><\/p>\n<p><strong><a href=\"https:\/\/blockads.fivefilters.org\/\" rel=\"noreferrer\" target=\"_blank\"><\/a><\/strong> <a href=\"https:\/\/blockads.fivefilters.org\/acceptable.html\" rel=\"noreferrer\" target=\"_blank\"><\/a><\/p>\n<p><a href=\"http:\/\/www.bbc.co.uk\/news\/science-environment-43076783\" rel=\"noreferrer\" target=\"_blank\">Original Article<\/a><\/p>\n<p> [contf] [contfnew]         <img decoding=\"async\" src=\"http:\/\/is3.mzstatic.com\/image\/thumb\/Purple118\/v4\/4c\/2c\/a9\/4c2ca936-441b-0a48-179b-40c734137d04\/source\/175x175bb.jpg\"\/> <\/p>\n<h5><a href=\"http:\/\/www.bbc.com\/news\" rel=\"noreferrer\" target=\"_blank\">BBC<\/a><\/h5>\n<p> [contfnewc] [contfnewc]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Media playback is unsupported on your device<\/p>\n<p>Scientists hav..<\/p>\n","protected":false},"author":1,"featured_media":64044,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[49],"tags":[],"class_list":["post-64042","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - 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