{"id":59149,"date":"2018-01-14T06:37:50","date_gmt":"2018-01-14T06:37:50","guid":{"rendered":"http:\/\/www.bnreport.com\/breast-cancer-survival-unaffected-by-faulty-gene-2\/"},"modified":"2018-01-14T06:37:50","modified_gmt":"2018-01-14T06:37:50","slug":"breast-cancer-survival-unaffected-by-faulty-gene-2","status":"publish","type":"post","link":"https:\/\/www.bnreport.com\/en\/breast-cancer-survival-unaffected-by-faulty-gene-2\/","title":{"rendered":"Breast cancer survival ‘unaffected by faulty gene’"},"content":{"rendered":"

Young breast cancer patients with faulty BRCA genes have the same survival chances as those without, a study has found.<\/p>\n

The researchers, who looked at almost 3,000 women, also found outcomes were the same whatever kind of treatment women had \u2013 including mastectomies.<\/p>\n

Experts say it means women can take time to decide if the radical surgery is right for them.<\/p>\n

The study did not look at preventative mastectomies.<\/p>\n

These are offered to women with faulty genes to cut their risk of developing cancer.<\/p>\n

Mutations in the BRCA1 and BRCA2 genes increase a woman's risk of breast cancer by four-to-eightfold and can explain why some families have lots of relatives diagnosed with breast cancer.<\/p>\n

The study, published in The Lancet Oncology<\/a>, found 12% of 2,733 women aged 18 to 40 treated for breast cancer at 127 hospitals across the UK between 2000 and 2008 had a BRCA mutation.<\/p>\n

The women's medical records were tracked for up to 10 years.<\/p>\n

During this time, 651 of the women died from breast cancer, and those with the BRCA mutation were equally likely to have survived at the two-, five- and 10-year mark as those without the genetic mutation.<\/p>\n

This was not affected by the women's body mass index or ethnicity.<\/p>\n

About a third of those with the BRCA mutation had a double mastectomy to remove both breasts after being diagnosed with cancer. This surgery did not appear to improve their chances of survival at the 10-year mark.<\/p>\n

But the researchers said surgery may still be beneficial for these patients to reduce their risk of a new cancer developing in the longer term.<\/p>\n

What is the BRCA gene?<\/h2>\n

It has been dubbed the 'Angelina Jolie gene', after the actress revealed she underwent preventative surgery on learning she had an up to 87% chance of developing breast cancer. <\/p>\n

Everyone has the BRCA genes, but when a fault occurs in one of them it can result in DNA damage and lead to cells becoming cancerous.<\/p>\n

Around 1 in 800 women in the general population are thought to carry the mutation and 5% of women with breast cancer in the UK will have a faulty form of the BRCA gene.<\/p>\n

The faulty genes are also linked to an increased risk of ovarian and prostate cancers, as well as breast cancer.<\/p>\n

Angelina Jolie had a preventative mastectomy, before she developed cancer. These types of surgery were not examined in this study.<\/p>\n

The study's author, Professor Diana Eccles, of the University of Southampton, said: "Women diagnosed with early breast cancer who carry a BRCA mutation are often offered double mastectomies soon after their diagnosis or chemotherapy treatment.<\/p>\n

"However, our findings suggest that this surgery does not have to be immediately undertaken along with the other treatment."<\/p>\n

'More time to decide'<\/h2>\n

Fiona MacNeill, of the Royal Marsden NHS Foundation Trust, who was not involved in the research, said: "This study can reassure young women with breast cancer, particularly those with triple negative cancer or who are BRCA carriers, that breast conservation with radiotherapy is a safe option in the first decade after diagnosis and double mastectomy is not essential or mandatory at initial treatment. <\/p>\n

She added: "In view of this, younger women with breast cancer can take time to discuss whether radical breast surgery is the right choice for them as part of a longer-term risk reducing strategy."<\/p>\n

Katherine Woods, from charity Breast Cancer Now said the findings "could enable many patients to make even more informed choices regarding their treatment". <\/p>\n

"In particular, being able to give some women with triple negative breast cancer the choice to delay a risk-reducing mastectomy would allow them to take back control of a major part of their treatment and offer them more time to recover from their initial therapy."<\/p>\n

She said she was now keen to understand how women fared more than 10 years after their diagnosis.<\/p>\n

The authors note the findings do not apply to older women.<\/p>\n

<\/a><\/strong> <\/a><\/p>\n

Original Article<\/a><\/p>\n

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BBC<\/a><\/h5>\n

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