Coronavirus<\/a> (COVID-19), can infect heart cells in a lab dish. This suggests it may be possible for heart cells in COVID-19 patients to be directly infected by the virus.
\n[contfnewc]
\nThe shock discovery was made using heart muscle cells produced by stem cell technology.[contfnewc]<\/p>\nAlthough many COVID-19 patients experience heart problems, the reasons remain unclear.<\/p>\n
Pre-existing cardiac conditions or inflammation and oxygen deprivation resulting from the infection have all been implicated.<\/p>\n
But there has until now been only limited evidence the SARS-CoV-2 virus directly infects the individual muscle cells of the heart.<\/p>\n
Dr Arun Sharma, of the Governors Regenerative Medicine Institute and first author of the study, said: \u201cWe not only uncovered that these stem cell-derived heart cells are susceptible to infection by novel coronavirus, but that the virus can also quickly divide within the heart muscle cells.<\/p>\n
\u201cEven more significant, the infected heart cells showed changes in their ability to beat after 72 hours of infection.\u201d<\/p>\n
The study also demonstrated human stem cell-derived heart cells infected by SARS-CoV-2 change their gene expression profile.<\/p>\n
This offers further confirmation the cells can be actively infected by the virus and activate innate cellular \u2018defence mechanisms\u2019 in an effort to help clear-out the virus.<\/p>\n
While these findings are not a perfect replicate of what is happening in the human body, the news may help investigators use stem cell-derived heart cells as a screening platform to identify new antiviral compounds capable of preventing viral infection of the heart, according to senior and co-author Dr Clive Svendsen.<\/p>\n
He said: \u201cThis viral pandemic is predominately defined by respiratory symptoms, but there are also cardiac complications, including arrhythmias, heart failure and viral myocarditis.\u201d<\/p>\n
The director of the Regenerative Medicine Institute and professor of Biomedical Sciences and Medicine added: \u201cWhile this could be the result of massive inflammation in response to the virus, our data suggest the heart could also be directly affected by the virus in COVID-19.\u201d<\/p>\n
Researchers also found treatment with an ACE2 antibody was able to blunt viral replication on stem cell-derived heart cells.<\/p>\n
This suggests the ACE2 receptor could be used by SARS-CoV-2 to enter human heart muscle cells.<\/p>\n
Dr Sharma added: \u201cBy blocking the ACE2 protein with an antibody, the virus is not as easily able to bind to the ACE2 protein, and thus cannot easily enter the cell.<\/p>\n
\u201cThis not only helps us understand the mechanisms of how this virus functions, but also suggests therapeutic approaches that could be used as a potential treatment for SARS-CoV-2 infection.\u201d<\/p>\n
The study used human induced pluripotent stem cells (iPSCs), a type of stem cell created in the lab from a person\u2019s blood or skin cells.<\/p>\n
IPSCs can make any cell type found in the body, each one carrying the DNA of the individual.<\/p>\n
Tissue-specific cells created in this way are used for research and for creating and testing potential disease treatments.<\/p>\n
Dr Eduardo Marb\u00e1n, executive director of the Smidt Heart Institute, said: \u201cThis work illustrates the power of being able to study human tissue in a dish.<\/p>\n
\u201cIt is plausible that direct infection of cardiac muscle cells may contribute to COVID-related heart disease.\u201d
\n[contfnewc]
\n[contfnewc]
\n[contfnewc]<\/p>\n
SOURCE<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"CORONAVIRUS can potentially infect your heart, a disturbing new study into the deadly pandemic has r..<\/p>\n","protected":false},"author":1,"featured_media":150428,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[49],"tags":[],"class_list":["post-150427","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science"],"yoast_head":"\n
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