Covid-19<\/a> are over 65 years of age with a greater than 23-fold increased risk of death.
\n[contfnewc]<\/p>\nThis additional time allows the virus to duplicate and cause severe symptoms \u2013 which may be worsened by pre-existing health conditions.<\/p>\n
But Harvard experts say this could be avoided with NAD boosters, a relatively new class of anti-ageing drugs.<\/p>\n
Lower levels of NAD+ in the system due to old age are believed to impair biological functions vital to health, which might be partly responsible to age-related diseases.<\/p>\n
One of the paper authors said NAD is the \u201cclosest weve gotten to a fountain of youth\u201d.<\/p>\n
NHS data shows of hospitalised coronavirus patients, 72 percent are over the age of 60.<\/p>\n
Furthermore, over 91 percent of patients who have died from the disease in England (total 20,853) are over the age of 60, data shows.<\/p>\n
The Harvard paper, which is yet to be peer reviewed by other experts, said: \u201cThe most exciting and potentially impactful technologies to treat Covid-19 are those that activate the body\u2019s defences against ageing.<\/p>\n
\u201cIt may even be possible to reset the age of cells and tissues so currently high-risk individuals can respond to viral infections as though they were young.\u201d<\/p>\n
The Blavatnik Institute at Harvard Medical School researchers said the severity of Covid-19 symptoms vary depending on how their system responds to the virus when it enters the body.<\/p>\n
Pre-existing health conditions, such as heart disease and diabetes, fail to explain exactly why the elderly are less resilient, the team said.<\/p>\n
An effective immune system response is to recognise the virus, alert the body to it and then destroy it with speed and then clear it from the body.<\/p>\n
A young persons immune cells identify the coronavirus when it first enters the upper respiratory tract.<\/p>\n
The mechanisms where the immune cells fight off the virus to stop the spread are \u201cknown to be dysfunctional\u201d in the elderly, the paper said.<\/p>\n
Viral alert signals are slow, resulting in a greater number of virus duplicates, and subsequently the virus accessing the lower respiratory tract where it can affect more cells.<\/p>\n
During ageing, the immune system changes in two fundamental ways which are \u201cmajor drivers of the high mortality rates in older patients\u201d, according to the research.<\/p>\n
Firstly, there is a gradual decrease in immune activity, called immunosenescence, which diminishes the body\u2019s ability to identify pathogens and act accordingly.<\/p>\n
The second immune change is a chronic increase in inflammation. It means the body avidly recognises a pathogen but does not effectively respond to it.<\/p>\n
NAD boosters are supplements that contain nicotinamide riboside, a form of vitamin B3. When taken as a supplement, the body converts the nicotinamide riboside to NAD+ \u2013 the coenzyme found in younger people.
\n[contfnewc]
\nDavid Sinclair, an author of the recent Harvard paper, said at the time: \u201cNAD+ is the closest weve gotten to a fountain of youth.<\/p>\n
\u201cIts one of the most important molecules for life to exist, and without it, youre dead in 30 seconds.\u201d<\/p>\n
The team also said NAD boosters and other techniques may be needed to improve the effectiveness of vaccines, which typically are weaker in the elderly.<\/p>\n
They write: \u201cIn the aged, immune responses to vaccination are often weak or defective<\/p>\n
\u201cTherefore, in designing vaccines against SARS-CoV-2, it will be important to consider that older people may not respond as well to vaccines as young people.\u201d
\n[contfnewc]
\n[contfnewc]<\/p>\n
READ MORE FROM SOURCE: https:\/\/www.express.co.uk\/news\/science\/1277386\/elderly-coronavirus-wonder-drug-harvard-research-coronavirus-latest-science-breakthrough<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"ELDERLY Covid-19 patients could be given anti-ageing drugs in a bid to restore their immune system s..<\/p>\n","protected":false},"author":1,"featured_media":143830,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[49],"tags":[],"class_list":["post-143829","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science"],"yoast_head":"\n
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