{"id":122482,"date":"2019-06-12T06:10:14","date_gmt":"2019-06-12T06:10:14","guid":{"rendered":"https:\/\/www.bnreport.com\/a-tiny-crater-on-viruses-behind-the-common-cold-may-be-their-achilles-heel\/"},"modified":"2019-06-12T06:10:14","modified_gmt":"2019-06-12T06:10:14","slug":"a-tiny-crater-on-viruses-behind-the-common-cold-may-be-their-achilles-heel","status":"publish","type":"post","link":"https:\/\/www.bnreport.com\/en\/a-tiny-crater-on-viruses-behind-the-common-cold-may-be-their-achilles-heel\/","title":{"rendered":"A tiny crater on viruses behind the common cold may be their Achilles heel"},"content":{"rendered":"

A newly discovered indentation on the surface of viruses that cause many illnesses, including the common cold, could be their Achilles heel \u2014 and a possible target for effective drugs.<\/p>\n

When scientists tested antiviral compounds on cells grown in the lab, the team found one that blocked the replication of an enterovirus. Cryo-electron microscopy revealed that the compound binds to and appears to jam a previously unknown pocket on the viruss protein shell<\/a>, researchers report online June 11 in PLOS Biology<\/em>.<\/p>\n

Additional testing suggests that the pocket is widespread among picornaviruses, the viral family that includes enteroviruses \u2014 which cause hand, foot and mouth disease as well as more dangerous infections \u2014 and rhinoviruses, responsible for the common cold. There are no antiviral medications available to treat these pathogens.<\/p>\n

The pocket \u201cis an excellent target for antivirals\u201d that may be effective against many of these types of viruses, says Susan Hafenstein, a structural virologist with the College of Medicine at Penn State who was not involved in the study.<\/p>\n

These viruses mutate very frequently, which makes it \u201ceasier for them to escape a drug,\u201d she says. To identify drug targets in the viruses, \u201cit is essential to identify key working components\u201d that these pathogens need to survive.<\/p>\n

During an infection, viruses inject their genetic material into cells and take over the cellular machinery to make more viral particles. In picornaviruses, a protein shell surrounds the viruss inner core of genetic material. Previous research suggests the shell changes shape when these viruses are ready to expel their genetic payload during an infection.<\/p>\n

But a chemical compound, identified by structural virologist Sarah Butcher of the University of Helsinki, virologist Johan Neyts of the University of Leuven in Belgium andRead More \u2013 Source<\/strong><\/a>
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science news<\/a><\/h5>\n

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A newly discovered indentation on the surface of viruses that cause many illnesses, including the co..<\/p>\n","protected":false},"author":1,"featured_media":122483,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[49],"tags":[],"class_list":["post-122482","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science"],"yoast_head":"\nA tiny crater on viruses behind the common cold may be their Achilles heel - Business News Report<\/title>\n<meta name=\"description\" content=\"A newly discovered indentation on the surface of viruses that cause many illnesses, including the co..\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.bnreport.com\/en\/a-tiny-crater-on-viruses-behind-the-common-cold-may-be-their-achilles-heel\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A tiny crater on viruses behind the common cold may be their Achilles heel - 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