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WEDNESDAY, Oct. 18, 2017 (HealthDay News) — When it comes to exercise, can you get too much of a good thing? Possibly, suggests a new study that found white men who exercise more than seven hours a week have an 86 percent higher risk of developing plaque build-up in their arteries. No such elevated risk was seen among either black men or women. Plaque build-up is a critical warning sign for possible future heart disease risk. "We were surprised by the finding, mainly because we essentially think of exercise as medicine. And we've never thought of exercise as perhaps having an upper limit in terms of its cardiovascular benefit," said study author Deepika Laddu. She's an assistant professor of physical therapy at the College of Applied Health Sciences at the University of Illinois at Chicago. But Laddu doesn't want any men to hang up their running shoes just yet, because there are many questions that remain to be answered. "What we saw is only an association, and we cannot say that high physical activity actually causes plaque build-up in white men," she noted. "And we certainly do not mean to say that exercise is bad for you. In fact, it could perhaps be that white men already face a higher than average risk for plaque build-up than other men, and that exercise actually prevents this plaque from rupturing, which is when things get bad. We just don't know," Laddu explained. "Much more research will be needed to understand what is really going on." At least one other expert agreed this doesn't mean people should stop exercising. Dr. Gregg Fonarow, a professor of cardiology at the University of California, Los Angeles, said the findings do not instantly wash away the "balance of data [that] suggest that higher levels of leisure time and total physical activity are associated with lower risk cardiovascular events." "However, it should be recognized that exercise alone cannot overcome other cardiovascular risk factors," he added. "And it is vital to maintain health levels of blood pressure, cholesterol and body weight, as well as not smoke, even if one is engaging in regular rigorous physical activity." To explore how exercise might impact heart health over time, the investigators recruited nearly 3,200 white and black men and women. All enrolled when they were between the ages of 18 and 30, and all resided in one of four cities: Birmingham, Chicago, Minneapolis or Oakland. The researchers followed the study volunteers from 1985 to 2011. During that time, participants self-reported their physical activity routines and showed up for at least three follow-up exams, which included CT scans to measure plaque build-up. Current U.S. physical activity guidelines recommend 150 minutes of moderate activity or 75 minutes of vigorous activity weekly. Participants were sorted into three groups, depending on average exercise levels. One group exercised below the guidelines level. Another group met the guidelines, and a final group exercised three times more than the guideline level. "We had 25 years of exercise patterns that we could look at, in individuals who started out as being young adults up through middle-age," Laddu said. In the end, the study team found that overall — when pooling race and gender — those who were among the most frequent exercisers were 27 percent more likely to develop plaque build-up by the time they had reached middle age. But after breaking the numbers down further, the authors determined that only high-exercising white men faced a greater risk for developing plaque build-up then their low-exercising peers. "But again, we can't say physical activity is causing plaque build-up," Laddu reiterated. She also acknowledged the study had limitations. For one, she noted that very few of the high exercisers were black, making it difficult to draw definitive conclusions. "And we really have no idea yet what may be biologically at play that might lead to differences in the way exercise affects [plaque build-up] in some people and not others," Laddu added. "But what I can say is that maybe this study indicates that doctors should not assume that their patients are healthy simply because they check off the exercise box," she said. "Maybe there are other things that they need to look at when considering a patient's overall medical profile." The study was published Oct. 16 in the Mayo Clinic Proceedings. More information There's more information on exercise and heart health at American Heart Association. Let's block ads! (Why?) Original Article
THURSDAY, Oct. 19, 2017 (HealthDay News) — Is a "nose job" worth it? And if so, how much? A new study suggests that casual observers may think patients who undergo such procedures are more attractive, more successful and healthier. "While we are not suggesting that [a nose job] is the only way to improve one's appearance, improving our attractiveness and health as compared to others conveys a competitive advantage," said study co-author and plastic surgeon Dr. Lisa Ishii. More than 220,000 "nose reshaping" procedures — known as rhinoplasty — were performed in the United States in 2016, up 2 percent from the previous year, according to the American Society of Plastic Surgeons. The procedures are nearly as common as liposuction. The new study examines how "casual observers" perceive people after they've had a nose job, said Ishii, a plastic surgeon and associate professor at Johns Hopkins School of Medicine in Baltimore. "Patients seeking rhinoplasty do so for two main reasons: to improve their self-perception and to improve how others perceive them," she said. "We wanted to measure the second one." The researchers recruited 473 people online to evaluate the appearance of 13 rhinoplasty patients. Observers ranged in age from 18 to 73. Most were female and white, and highly educated. The researchers deemed the patients' post-op results "optimal." They showed the observers photos taken before the nose reshaping and at least 6 months after. But they didn't reveal whether they were "before" or "after" images, and the observers never saw more than one picture of the same patient. The patients were mostly female, with an average age of 34. Most "had nose problems that were visible to the casual observer and they wanted to look better," Ishii said. She added that a prior study showed that the casual observer "actually picks up on even subtle nasal deformities." Her team asked the observers to rate patients in terms of attractiveness, success level and overall health based on their photos. On a scale of 1 to 100, the average patient's attractiveness rating improved by 14 points after remodeling, the researchers found. Ratings of success and health rose 9 and 10 points, respectively, after surgery. Ishii called the degree of improvement significant, and said this gives patients information about how nose jobs may affect them. "More attractive people are more successful," she said. "It's up to patients to decide whether that's worth it to them." Insurers don't usually cover nose jobs, however. The cost can range from $6,000 to $25,000 "depending on the complexity of the procedure and the reputation of the surgeon," said plastic surgeon Dr. Clinton Humphrey. He's an associate professor with the University of Kansas Health System. "It is important not to misinterpret these study results," cautioned Humphrey, co-author of a commentary accompanying the new research. "This study included only patients with what were judged by surgeons to be 'ideal' results. Rhinoplasty continues to be one of the most challenging cosmetic surgical procedures," he said. "While I always strive to achieve the best possible outcome in every one of my rhinoplasty patients, I do not achieve an 'ideal' result every time," Humphrey said. "It would be a mistake to read this study and conclude that every patient who undergoes rhinoplasty can expect to be perceived as more successful, healthier, and more attractive," he added. Still, he said, "patients should feel reassured that what we as rhinoplasty surgeons consider to be 'ideal' results are also viewed very favorably by the average person," Humphrey said. "As a surgeon, this study tells me that when I execute a successful rhinoplasty, I have an opportunity to positively impact my patient in a really significant way." The study appears Oct. 19 in the journal JAMA Facial Plastic Surgery. More information For more about nose jobs, visit the American Society of Plastic Surgeons. Let's block ads! (Why?) Original Article
THURSDAY, Oct. 19, 2017 (HealthDay News) –Yescarta (axicabtagene ciloleucel) has been approved by the U.S. Food and Drug Administration as the first form of gene therapy for a non-Hodgkin lymphoma (NHL) form of cancer. Diffuse large B-cell lymphoma is the most common form of this immune system cancer in adults, the agency said in a news release. Some 72,000 cases of NHL are diagnosed each year in the United States, and the Diffuse large-B cell form represents about a third of these cases, the FDA added. This is only the second form of gene therapy approved by the FDA. The technique uses cells from the patient's own immune system to create a custom treatment to help fight the cancer. In this case, the patient's white blood cells called T-cells are modified to include a new gene that targets and kills lymphoma cells, then re-infused back into the patient. "In just several decades, gene therapy has gone from being a promising concept to a practical solution to deadly and largely untreatable forms of cancer," said FDA Commissioner Dr. Scott Gottlieb. "We remain committed to supporting the efficient development of safe and effective treatments that leverage these new scientific platforms." Yescarta is approved for adults for whom at least two other types of treatment have failed. The therapy was evaluated in clinical studies involving more than 100 adults. Slightly more than half of people given the therapy ended up in "complete remission," the FDA said. The therapy includes a boxed warning of a heightened risk of high fever, flu-like symptoms and life-threatening neurologic symptoms, the FDA said. Patients must be informed of these risks before receiving the therapy. Other potential side effects include serious infections, low blood-cell counts and a weakened immune system. Hospitals that provide the therapy will have to be specially certified, the FDA said. The therapy is produced by Los Angeles-based Kite Pharma Inc., which as a condition of approval must conduct studies of the therapy's long-term effects, the agency said. More information Visit the FDA to learn more. Let's block ads! (Why?) Original Article [contf] [contfnew] [hhm]Health[hhmc] [contfnewc] [contfnewc]
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