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Yoga + Aerobics Doubles Heart Benefits

FRIDAY, Oct. 20, 2017 (HealthDay News) — A combination of yoga and aerobic exercise may benefit people with heart disease, according to a new study. "Combined Indian yoga and aerobic exercise reduce mental, physical and vascular stress and can lead to decreased cardiovascular mortality and morbidity," said study authors Sonal Tanwar and Dr. Naresh Sen, from Hridaya Ganesha Sunil Memorial Superspeciality Hospital in Jaipur, India. The study included 750 obese Indian heart disease patients with type 2 diabetes. They were divided into three groups. A group of 225 patients did aerobic exercise, a group of 240 did yoga, and the remaining 285 did both. All three groups saw improvements in their heart disease risk factors after participating in three sessions of the activities lasting six months each. Blood pressure went down similarly for the aerobic exercise-only and yoga-only groups. These groups also had similar improvements in total cholesterol, triglycerides and bad LDL cholesterol. Weight and waist circumference also went down similarly for both of these groups, the study said. But patients who did both yoga and aerobic exercise had two times greater reductions for those measures than the other groups. They also had significant improvements in heart function and exercise capacity, the researchers said. The study was to be presented Thursday at the Emirates Cardiac Society Congress. This meeting is in collaboration with the American College of Cardiology Middle East Conference, in Dubai. "Heart disease patients could benefit from learning Indian yoga and making it a routine part of daily life," Tanwar and Sen said in a meeting news release. Findings presented at meetings are typically viewed as preliminary until published in a peer-reviewed journal. More information The U.S. Centers for Disease Control and Prevention has more on heart disease. Let's block ads! (Why?) Original Article

Health

How Many Mutant Genes Drive Cancer?

FRIDAY, Oct. 20, 2017 (HealthDay News) — Depending on the cancer, between one and 10 genetic mutations are needed to trigger the development of tumors, a new study reports. "We have addressed a longstanding question in cancer research that has been debated since the 1950s: How many mutations are needed for a normal cell to turn into a cancer cell?" said study author Peter Campbell, with the Wellcome Trust Sanger Institute in Cambridge, England. "The answer is — a small handful," he added. "For example, about four mutations per patient, on average, drive liver cancers, whereas colorectal cancers typically require 10 or so driver mutations." The findings, culled from analyses of more than 7,600 tumors from 29 types of cancer, could help lead to more targeted therapies for treatment, the researchers said. The researchers explained that they developed a way to determine which genes are involved in cancer evolution and how many mutations in those genes drive cancer. It may someday be possible to use such approaches to identify which mutations are responsible for an individual patient's cancer, the researchers said. Study co-author Inigo Martincorena is also a research scientist at Wellcome Trust. "In the study, we revealed that around half of these key mutations driving cancer occur in genes that are not yet identified as cancer genes," he said in an institute news release. "There is already much insight into the most important genes involved in cancer; but there are many more genes yet to be discovered," Martincorena said. "We will need to bring together even larger numbers of cancers studied by DNA sequencing, into the tens of thousands, to find these elusive genes." The researchers also found that the mutations responsible for cancer are usually well-tolerated by cells in the body. This was surprising because mutations that people inherit from their parents are often poorly tolerated and are generally eliminated over generations, the researchers said. "This research shows that across cancer types a relatively consistent small number of such mutated genes is required to convert a single normal cell into a cancer cell, but that the specific genes chosen differ according to cancer type," said study co-author Mike Stratton, director of the institute. "The study also shows that we have not yet identified many of these driver genes, and they will be the target for further searching in the future. This increasingly precise understanding of the underlying changes that result in cancer provides the foundation for the discovery and use of targeted therapies that treat the disease," Stratton said. The study was published Oct. 19 in the journal Cell. More information The American Cancer Society has more on cancer. Let's block ads! (Why?) Original Article

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Kidney Failure Can Isolate Young Patients

FRIDAY, Oct. 20, 2017 (HealthDay News) — Kidney failure takes an especially tough toll on young adults, affecting their employment and relationships, researchers report. Young people with kidney failure are less likely to have jobs or be in long-term relationships than others their age, according to a new British research review. "It is vital to understand how kidney failure affects social goals, because by defining these we can seek interventions to improve areas of deficit," said Dr. Alexander Hamilton, of the University of Bristol in England. His team analyzed 60 published studies that included nearly 16,000 kidney failure patients aged 16 to 30. They were either on dialysis or had received a kidney transplant. Compared to their healthy peers, these young people had a worse quality of life and were more likely to be unemployed and to live in their parents' home, the study found. They also were less likely to be married or have a romantic partner. These social, employment and lifestyle issues were worse among those on dialysis than among those who'd had a kidney transplant, the researchers said. There were no differences between kidney failure patients and their healthy peers in terms of education levels or rates of smoking and drinking. The study was published in the Oct. 19 issue of the Clinical Journal of the American Society of Nephrology. "We know that most young people with end-stage kidney disease have a kidney transplant, but they are high-risk for the transplanted kidney to fail," Hamilton said in a journal news release. While much attention has been paid to the transition between pediatric and adult care for kidney patients, he said it's also essential to look at the social ramifications among this younger adult age group. "These areas really matter to patients," Hamilton said. More information The American Kidney Fund has more on kidney failure. Let's block ads! (Why?) Original Article

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